2002 57(3):253-257.), antifungal and antibacterial ( Kumar et al., 2010a Kumar GVS, Rajendraprasad Y, Mallikarjuna BP, Chandrashekar SM, Kistayya C. Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolothiadiazoles. 2014 7(6):955-963.), antiviral ( Kritsanida et al., 2002 Kritsanida M, Mouroutsou A, Marakos P, Pouli N, Papakonstantinou-Garoufalias S, Pannecouque C, Witvrouw M, De Clercq E. Synthesis and pharmacological evaluation of 3-diphenylmethyl-6-substituted-1,2,4-triazolo-1,3,4-thiadiazoles: A condensed bridgehead nitrogen heterocyclic system. Akhter, Hassan, Amir, 2014 Akhter MW, Hassan MZ, Amir M.
Design, synthesis and docking studies of 2-benzoxazolinone-based 1,2,4-triazoles as proinflammatory cytokine inhibitors. Haider et al., 2014 Haider S, Alam MS, Hamid H, Dhulap A, Umar S, Yar MS, Bano S, Nazreen S, Ali Y, Kharbanda C. Novel thiazolo-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies. Sarıgöl et al., 2015 Sarıgol D, Uzgoren-Baran A, Tel BC, Somuncuoglu EI, Kazkayasi I, Ozadali-Sari K, Unsal-Tan O, Okay G, Ertan M, Tozkoparan B. Heterocyclic system containing bridgehead nitrogen atom: synthesis and pharmacological activities of some substituted 1,2,4-triazolo-1,3,4-thiadiazoles. 2007 15(7):2601-2610.), anti-inflammatory, analgesic ( Mathew, Keshavayya, Vaidya, 2006 Mathew V, Keshavayya J, Vaidya VP. Clubbed thiazoles by MAOS: A novel approach to cyclin-dependent kinase 5/p25 inhibitors as a potential treatment for Alzheimer’s disease. Moreover, some 1,2,4-triazoles and 1,2,4-triazolothiadiazoles derived from 4-amino-3-thioxo-1,2,4-triazoles are associated with diverse pharmacological activities such as anti-Alzheimer’s ( Shiradkar, et al., 2007 Shiradkar MR, Akula KC, Dasari V, Baru V, Chiningiri B, Gandhi S, Kaur R. 1,2,4-Thiadiazole ring is associated with a wide variety of biological activities named antimicrobial, antimycobacterial, anticonvulsant, antidepressant, antihypertensive, and analgesic agents. 2001 36(2):109-126.).Ī large number of N-bridged heterocycles derived from 1,2,4-thiadiazole nucleus are important pharmacological agents and there is a significant amount of research on this class of compounds. Cyclooxygenase inhibitors-current status and future prospects.
Their clinical efficacy is closely related to their ability to inhibit both COX-1 and COX-2 isoforms of the enzyme cyclooxygenase (COX) which is also referred to as prostaglandin H2 synthase since it catalyzes the conversion of arachidonic acid to prostaglandin H2 (PGH2) ( Dannhardt, Kiefer, 2001 Dannhardt G, Kiefer W. Non-steroidal anti-inflammatory drugs (NSAIDs) represent a heterogeneous family of pharmacologically active compounds used to alleviate acute and chronic inflammation, pain, and fever.
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